Monday, June 22, 2020

How to identify the deterioration of medicines

Improper drug storage methods or long storage time can easily lead to deterioration and even produce toxic substances, so attention must be paid. How to identify whether the medicine has deteriorated?

1. Capsules and capsules: Capsules are extremely susceptible to moisture, and should not be taken if they are obviously softened, cracked, leaking oil, or sticking to each other; capsules are often difficult to judge whether they have deteriorated from color, but if they have a bad smell Don't take it anymore.

2. Suppositories, eye ointments and other ointments: if there is an odor, rancidity, or obvious dry particles and thinness, discoloration, separation of water and oil, etc., it can not be used again. Contraceptive plugs are easy to deform when the room temperature is high, and can still be used after deformation, but they cannot be used if they change color. Most of the color changes are chemical reactions that have occurred, and the reduction in drug efficacy will affect the contraceptive effect.

3. Tablets: White tablets turn yellow, the surface is rough, evacuated or deliquesced, or there is crystal precipitation. The tablets have spots, mold, moths, odor, etc., which cannot be used. Ultraviolet rays in sunlight can accelerate the deterioration of drugs, especially vitamin C and antibiotics. The color will change after exposure to light, reducing the efficacy of the drug and even turning it into a harmful substance. Some medicines easily absorb moisture in the air and will soon deteriorate. For example, aspirin will be decomposed into salicylic acid and acetic acid after being damp, producing a strong sour taste, greatly irritating to the gastrointestinal tract, and severely causing gastric mucosal bleeding, so it is not appropriate to take it again.

4. Syrup: Regardless of the color of the liquid, it should be clear and free of foreign matter. Do not take it if there is more sediment or discoloration

5. Sugar-coated tablets: Yeast tablets, vitamin B1, calcium gluconate, and some sugar-coated sugar-coated tablets, etc. If the tablets are stuck to each other, black spots appear, the sugar coating layer is cracked, moldy, smelly, etc. should not be taken.

6. Granules: Normal granules are dry granules that can be evacuated and rolled. If they are found to be sticky, melted, or smelly, do not take them.

7. Injections and powder injections: These two types of drugs are directly injected into the blood through intravenous injection, and they are very strict in use. Once the color changes and precipitates, such as darker color, turbidity, moldy spots, flocs, etc., they can not continue to use . It is absolutely impossible to use powder injections when they are agglomerated. Some injections, such as mannitol, will produce crystals at low temperatures in winter. Although they can be dissolved after heating in water, it is not a drug deterioration, but there may be crystals that are not visible to the naked eye, so it is not recommended to continue to use.

8. Eye drops and nasal drops: If there are crystals or flocs in the liquid, or if they are cloudy or discolored, do not use them.

There are also some medicines that have not changed significantly in appearance, but the interior has deteriorated. Therefore, any drug that has passed the expiration date can no longer be used. The expiration date refers to the period during which the drug can maintain its quality under the prescribed storage conditions. If the validity period of a drug is June 6, 2013, it means that this product will not be used until June 7, 2013. If the expiration date of a drug is June 6, 2013, it indicates that the product can be used until June 5, 2013. If the batch number of a drug is 20130922, the validity period is 3 years, indicating that this product can be used until September 21, 2016. However, it should be noted that the validity period of the drug is not equal to the insurance period. If improper storage, even within the validity period, it may cause the deterioration of the drug.

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