Tuesday, June 23, 2020

How should Parkinson prevent it?

So far, the exact cause of Parkinson's disease is not yet clear, so the preventive measures lack precise targeting. However, many studies have confirmed that there are certain causal relationships between the above-mentioned risk factors and degeneration and necrosis of midbrain substantia nigra dopamine neurons. If corresponding preventive measures can be taken against the risk factors, the incidence of Parkinson's disease can be prevented and the course of disease can be delayed. Progress is definitely beneficial.

Primary prevention (no disease prevention)

1. Those who have a family history of Parkinson's disease and related gene carriers, and those who are exposed to toxic chemicals should be considered as high-risk groups. They must be closely monitored and followed up, regular physical examinations, and health education should be strengthened. Self-protection should be emphasized.

2. Strengthen the environmental protection of industrial and agricultural production, reduce the discharge of harmful gases, sewage and pollutants, and strengthen the labor protection for harmful workers.

3. Improve drinking water facilities in rural and urban areas, protect water resources, reduce pollution of river water, reservoir water, pond water and well water, and ensure that the general public can drink safe and sanitary drinking water.

4. The elderly should use phenothiazines, reserpines and butyrylbenzenes with caution.

5. Pay attention to the prevention and treatment of senile diseases (hypertension, hyperlipidemia, hyperglycemia, cerebral arteriosclerosis, etc.), enhance physical fitness, delay aging, prevent atherosclerosis, and play a positive role in preventing Parkinson's disease.

Secondary prevention (early detection, early diagnosis, early treatment)

1. Early diagnosis. Parkinson's disease has a long subclinical period. If pre-clinical diagnosis techniques such as olfactory dysfunction, PET scan, mitochondrial DNA, dopamine antibody, cerebrospinal fluid chemistry, and electrophysiology can be carried out as soon as possible, the subclinical Parkinson's disease will be detected as soon as possible. , The use of neuroprotective agents (such as vitamin E, SOD, glutathione and glutathione peroxidase, neurotrophic factors, seligirin) treatment may delay the entire clinical process.

2. In the early stage of Parkinson's disease, although the substantia nigra and striatum nerve cells decrease, the dopamine secretion increases compensatively. At this time, the dopamine content in the brain does not decrease significantly, which is called the compensatory period. Physical therapy, medical sports, tai chi, hydrotherapy, massage, qigong, acupuncture and other treatments can be used to maintain daily work and life, and delay the application of anti-tremor paralysis drugs as much as possible. However, some people advocate the early application of low-dose levodopa to reduce complications, which varies from person to person. 3. During the decompensation period of Parkinson's disease, medication should be used.

Tertiary prevention (delay development, prevent disability, and improve quality of life)

1. Actively carry out non-drug treatments such as physiotherapy, physical therapy, acupuncture, massage, etc. and Chinese and Western medicines or surgery to delay the development of the disease.

2. Pay attention to psychological counseling, appease and spiritual care, ensure adequate sleep, avoid emotional tension and agitation, in order to reduce the inducing factors of increased muscle tremor.

3. Actively encourage patients to take the initiative to exercise, such as eating, dressing, washing, etc. People with language barriers can try to practice pronunciation aloud in the mirror. Strengthen joint and muscle activity and labor training, maintain limb motor function as much as possible, pay attention to prevent wrestling and limb deformity and disability.

4. Those who stay in bed for a long time should strengthen life care, pay attention to cleanliness, turn over and pat their backs frequently to prevent complications such as falling pneumonia and decubitus infection. Most Parkinson’s disease is caused by lung or other system infections such as urinary system . Pay attention to diet and nutrition, and give nasal feeding when necessary, to keep the stool smooth. To continuously enhance physical fitness, improve immune function and reduce mortality.

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