Tuesday, June 23, 2020

Drugs not suitable for asthma patients?

(1) Drugs should be banned:

① The non-selective β-blocker propranolol has a blocking effect on both β1 and β2 receptors, which can cause broncho-smooth muscle spasm and nasal mucosal capillary contraction. Asthma patients can deteriorate rapidly after use.

② Neostigmine, galantamine, organic phosphates and other anticholinesterase drugs can be combined with cholinesterase after entering the human body, so that the phenol choline is greatly increased, thereby causing the bronchi to contract; pilocarpine and cresol Choline and other exams, the large website collection of choline drugs can directly excite bronchial smooth muscle ~ M-receptors, so they can induce and aggravate bronchial asthma.

③ Limianning, hypnone, codeine, morphine, fentanyl, magnesium sulfate, and malilan can cause respiratory depression, exacerbate asthma, and should be disabled during asthma attacks.

(2) Drugs that should be used with caution:

① Penicillins, erythromycin, neomycin, cephalosporins, tetracyclines, streptomycin, chloramphenicol, furantidine, rifampicin, antisera, vaccines, plasma, Chinese patent medicines containing animal heterosexual proteins Preparations, as well as drugs sensitized due to individual differences, can be used as antigens to cause allergic reactions, causing bronchoconstriction and inducing asthma.

② Analgesic, thiophene, thiopental, iodine-containing contrast agent, hydralazine, enflurane, and progesterone can cause mast cells to release histamine and other different media, which can cause bronchoconstriction and induce asthma.

③ Aspirin and compound preparations containing aspirin can cause asthma in some patients.

④ The selective beta-blocker metoprolol (betaloc) and amethoxolol mainly block the β1-receptor and have minimal effect on the β2-receptor, so it should be used with caution.

⑤ β-receptor stimulants isoproterenol and epinephrine aerosols, and theophylline drugs can dilate bronchial smooth muscle and have good effect in the early stage of asthma. However, if used for a long time in large quantities, it will worsen asthma and even cause sudden death. Therefore, long-term large-scale use of these drugs for bronchial asthma should be avoided.

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