Tuesday, June 23, 2020

Causes of cerebral palsy

The causes of cerebral palsy are more complicated. Although some have been clarified, some are still unclear. From the perspective of active prevention, every child with cerebral palsy should make every effort to find and analyze its cause, and widely publicize preventive measures, which has a positive significance in reducing the incidence.

Common causes of cerebral palsy are:

Heredity: The genetic material present in sperm, egg, or fertilized egg has changed, making the second-generation disease called genetic disease. Most genetic diseases have a family history, and more often occur in families where close relatives get married. Cerebral palsy due to genetic disease accounts for a very high proportion. There are 3 children with cerebral palsy in the same family in the hospital. An autosomal recessive genetic disease of humans, phenylketonuria, is due to a congenital lack of an enzyme, which causes the body's metabolic disorders and leads to cerebral palsy. Such a family can also have multiple children suffering from cerebral palsy at the same time. Therefore, pre-marital and antenatal genetic counseling should be done well, and marriage of close relatives should be forbidden in order to do a good job in eugenics.

Infected pregnant women, especially in the first three or four months of pregnancy, should try to avoid infection. If you suffer from viral diseases (such as influenza, shingles, rubella, etc.), it may affect the development of the fetal brain, so that a series of symptoms of cerebral palsy may occur after the fetus is born. According to a case analysis report, some of the mothers of children with cerebral palsy in this hospital had viral eye conjunctivitis (red eye disease) when they were 3 months pregnant, which is closely related to the occurrence of cerebral palsy in their children. Therefore, care must be taken during pregnancy to prevent infectious diseases, especially viral diseases.

Cerebral palsy due to cerebral hypoxia is very common in the clinic. — There are many reasons for hypoxia in the fetal brain, such as: threatened abortion, placental abruption, umbilical cord around the neck, umbilical cord knot, etc. These factors can affect the blood circulation of the fetus and lead to hypoxic state, which in turn affects the fetal brain development or Damage the brain. Neonatal cerebral hypoxia is often caused by suffocation, amniotic fluid inhalation, respiratory distress syndrome, and the inappropriate use of sedatives and anesthetics by the prenatal mother, which inhibits the newborn's respiratory center, causing gas exchange disorders, and decreased oxygen content in the blood. And the brain development is inhibited or injured, which leads to cerebral palsy.

Nuclear jaundice can cause hemolysis in newborns due to incompatibility of maternal and child blood types or other reasons. One of the characteristics of hemolysis is the severe jaundice of the skin around the body within 24-36 hours after birth. If it is not treated in time, the jaundice will continue to increase, further invading the central nervous system and staining the nucleus of the brain, so it is called nuclear jaundice. Once nuclear jaundice occurs, the child will have straight eyes, screams, angulation, twitching, etc. Cerebral palsy can be left after survival. Therefore, once it is found that babies less than 36 hours old have general jaundice, they must be vigilant and go to the hospital as soon as possible to prevent neonatal nuclear jaundice. Premature and low-birth-weight babies with a gestational age of less than 36 weeks are called premature babies. In general, twins or multiple twins are prone to premature delivery, and most of them are underweight. Premature infants and low-birth-weight infants often develop immaturely within the fetus, prone to suffocation and intracranial hemorrhage, causing brain cell damage and leaving cerebral palsy.

Pregnant women with metabolic disorders have pregnancy poisoning (shown as hypertension, edema, kidney damage, etc.), diabetes, etc. Due to metabolic disorders, the central nervous system of the fetus may be damaged, which may lead to cerebral palsy.

Improper medication for pregnant women. Exposure to poisons and poisoning can affect the development of the fetal nervous system. The two children with cerebral palsy in our hospital have a history of carbon monoxide, or gas coma, during their pregnancy. Due to gas poisoning, the oxygen content in the maternal blood is reduced, resulting in hypoxia of the fetus, which damages the development of the brain and causes cerebral palsy.

Trauma During pregnancy, if the mother suffers a trauma, it can stimulate the fetus to increase the number of fetal movements. Severe fetal movements can cause the umbilical cord to knot and twist, which can lead to blood circulation disorders and cause fetal hypoxia. A mother of a child with cerebral palsy in our hospital had a visceral rupture due to trauma at 3 months of pregnancy, underwent splenectomy under general anesthesia, and removed one side of the kidney. The mothers of the other two children with cerebral palsy also had a history of trauma from falling down the stairs during pregnancy. This shows that trauma during pregnancy may lead to cerebral palsy, pregnant women should be extra careful not to be traumatized.

Other than the above, the cause of some cerebral palsy is still unclear. For example, congenital craniocerebral malformation can cause cerebral palsy, but its actual mechanism and etiology. To be explored.

In summary, there are many causes of cerebral palsy, the most common are genetics, hypoxia infection, nuclear jaundice, premature delivery, poisoning, trauma and so on.

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